Benzimidazole derivatives useful as angiotensin II inhibitors

Details Benzimidazole derivatives useful as angiotensin II inhibitors Benzimidazole derivatives useful as angiotensin II inhibitors

1992-04-21

1993-10-05

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 548252, 548253, 5483094, A61K 31415, C07D23514, C07D23512, C07D23510

Patent

active

052505545

ABSTRACT:
Novel imidazole derivatives of the formula (I): ##STR1## wherein R.sup.1 is an optionally substituted alkyl group, R.sup.2 and R.sup.3 are independently a group capable of forming an anion or a group which can be changed thereinto, ring A is a benzene ring optionally having, besides the group shown by R.sup.2, further substituents, and X shows linkage of phenylene group and phenyl group directly or through a spacer whose atomic length is not more than 2 and a salt thereof, show antagonistic actions to angiotensin II, thus being useful as therapeutics for cardiovascular diseases.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.

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