Benzimidazole derivatives, their use, and compositions containin

Details Benzimidazole derivatives, their use, and compositions containin Benzimidazole derivatives, their use, and compositions containin

1980-04-30

1982-07-06

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548334, 548327, A61K 31415, C07D23518, C07D40512

Patent

active

043383300

ABSTRACT:
A derivative of benzimidazole of the general formula I: ##STR1## wherein: R.sub.1 represents a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7,C.sub.8,C.sub.9,C. sub.10,C.sub.11,C.sub.12,C.sub.13,C.sub.14,C.sub.15, C.sub.16,C.sub.17 or C.sub.18, a cycloalkyl radical C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7 or C.sub.8, a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4 or C.sub.5 substituted by one or more radicals selected from the group comprising:

REFERENCES:
patent: 3574218 (1971-04-01), Hideg et al.
patent: 4130413 (1978-12-01), Handte et al.
patent: 4212877 (1980-07-01), Keppe et al.
Rote Liste 1977/78, No. 26001-26025.
Crowther et al., J. Med. Chem., 1972, vol. 15(3), pp. 260-266.
Augstein et al., J. Med. Chem. 1973, vol. 16(11), pp. 1245-1251.
Bartsch et al., Drug Research 1977, vol. 27(5), pp. 1022-1026.
Crooks et al., J. Med. Chem. 1979, vol. 22(2), pp. 210-214.
Ullmann's Encyclopadie der Technischen Chemie, 4th Ed., vol. 12, 1976, Verlag Chemie, pp. 636-639.
Hackh's Chemical Dictionary, 4th Ed., pp. 288, 304 and 305, McGraw-Hill, New York, 1969.

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