Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-05-31
1999-03-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514376, 514394, 548132, 548159, 548165, 548226, 5483047, A01N 4378, C07D27106, C07D27762, C07D41700
Patent
active
058860142
ABSTRACT:
Compounds of formula (I): ##STR1## represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethlyl group; R represents hydrogen, alkyl, alkoxy, halogen, hydroxy, nitro, amino or aralkyl; and m is an integer from 1 to 5!; have valuable activity for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistance and diabetic complications.
REFERENCES:
patent: 4572912 (1986-02-01), Yoshioka et al.
patent: 4691027 (1987-09-01), Yoshioka et al.
patent: 4775687 (1988-10-01), Meguro et al.
patent: 4871762 (1989-10-01), Yoshioka et al.
patent: 4873255 (1989-10-01), Yoshioka et al.
patent: 5104888 (1992-04-01), Yoshioka et al.
patent: 5143930 (1992-09-01), Yoshioka et al.
patent: 5338855 (1994-08-01), Yoshioka et al.
patent: 5387596 (1995-02-01), Takebayashi et al.
patent: 5391565 (1995-02-01), Hindley
patent: 5578620 (1996-11-01), Fujita et al.
patent: 5614542 (1997-03-01), Horikoshi et al.
patent: 5614544 (1997-03-01), Sohda et al.
patent: 5624935 (1997-04-01), Fujita et al.
patent: 5688823 (1997-11-01), Fujita et al.
patent: 5739345 (1998-04-01), Fujita et al.
Sohda et al, "Studies on Antidiabetic Agents. II..sup.1) Synthesis of 5-4-(1-Methylcyclohexylmethoxy)benzyl!thiazolidine-2,4-dione (ADD-3878) and Its Derivatives", Chem. Pharm. Bull., 30, pp. 3580-3600(1982).
Fujita et al, "Reduction of Insulin Resistance in Obese and/or Diabetic Animals . . . a New Antidiabetic Agent", Diabetes, vol. 32, Sep. 1983, pp. 804-810.
Fujiwara et al, "Characterization of New Oral Antidiabetic Agent CS-045", Diabetes, vol. 37, Nov. 1988, pp. 1549-1558.
Chang et al, "The Hypoglycemic Effect of Ciglitazone in Obese, Hyperglycemic Animal Models", Prog. Clin. Biol. Res., 265, (1988) pp. 177-192.
Colca et al, "Ciglitazone, A Hypoglycemic Agent: Early Effects on the Pancreatic Islets of Ob/Ob Mice", Metabolism, vol. 37, No. 3, Mar. 1988, pp. 276-280.
Sohda et al, "Studies on Antidiabetic Agents", Arzneimittelforschung, Drug Res. 40(I), (1990) pp. 37-42.
Ikeda et al, "Effects of Pioglitazone on Glucose and Lipid Metabolism in Normal and Insulin Resistant Animals", Arzneimittelforschung, 40(2 Pt 1), (1990) pp. 156-162.
Sugiyama et al, "Effects of Pioglitazone on Glucose and Lipid Metabolism in Wistar Fatty Rats", Arzneimittelforschung, 40(3), (1990), pp. 263-267.
Colca et al, "Pioglitazone Hydrochloride Inhibits Cholesterol Absorption and Lowers Plasma Cholesterol Concentrations in Cholesterol-Fed Rats", Diabetes, vol. 40, Dec. 1991, pp. 1669-1674.
Saha et al, "Lipid abnormalities in tissues of the KKA.sup..gamma. mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol", Am. J. Physiol., 267(1 Pt 1), (1994) pp. E95-E101.
Oakes et al, "A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat", Diabetes, vol. 43, Oct. 1994, pp. 1203-1210.
Bowen, "The Effect of CP 68,722, a Thiozolidinedione Derivative, on Insulin Sensitivity in Lean and Obese Zucker Rats", Metabolism, vol. 40, No. 10, Oct. 1991, pp. 1025-1030.
Kemnitz et al, "Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure in Obese, Insulin-Resistant Rhesus Monkeys", Diabetes, vol. 43, Feb. 1994, pp. 1025-1230.
Keen, "Insulin Resistance and The Prevention of Diabetes Mellitis", N. Engl. J. Med., 331(18), Nov. 1994, pp. 1226-1227.
Yoshioka et al, "Antihypertensive Effects of CS-045 Treatment in Obese Zucker Rats", Metabolism, vol. 42, No. 1, Jan. 1993, pp. 75-80.
Dubey et al, "Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats", Am. J. Physiol., 265(4 Pt 2), 1993, pp. R726-R732.
Ohsumi et al, "Troglitazone Prevents the Inhibitory Effects of Inflammatory Cytokines on Insulin-Induced Anipocyte Differentiation in 3T3-L1 Cells" Endocrinology, vol. 135, No. 5, 1994, pp. 2279-2282.
Szalkowski et al, "Antidiabetic Thiazolidinediones Block the Inhibitory Effect of Tumor Necrosis Factor-.alpha. on Differentiation, Insulin-Stimulated Glucose Uptake, and Gene Expression in 3T3-L1 Cells", Endocrinology, vol. 136, No. 4, 1995, pp. 1474-1481.
Shikazumi et al, "The Effects of Pioglitazone on Glomerular Lesions in Wistar Fatty Rats", Journal of Japan Diabetes Society 38, 1995, (original copy and its English translation).
Zhang et al, "Effects of Pioglitazone on Calcium Channels in Vascular Smooth Muscle", Hypertension, vol. 24, No. 2, Aug. 1994, pp. 170-175.
Austin Patterson et al, The Ring Index, 2nd Edition, (American Chemical Society), p. 157 (1960).
Takao Yoshioka et al, "Studies on Hindered Phenols and Analogues. 1. Hypolipidemic and Hypoglycemic Agents with Ability To Inhibit Lipid Peroxidation", J. Med. Chem., vol. 32, 1989, pp. 421-428.
Takashi Sohda et al, "Studies on Antidiabetic Agents. 11..sup.1 Novel Thiazolidinedione Derivatives as Potent Hypoglycemic and Hypolipidemic Agents.sup.2 ", J. Med. Chem., vol. 35, 1992, pp. 2617-2626.
Joseph W. Kemnitz, Diane F. Elson, Ellen B. Roecker, Scott T. Baum, Richard N. Bergman and Martin D. Meglasson, "Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure in Obese, Insulin-Resistant Rhesus Monkeys", Diabetes, 43(2), 204-211 (1994).
Fujimoto Koichi
Fujita Takashi
Fujiwara Toshihiko
Horikoshi Hiroyoshi
Oguchi Minoru
Ngo Tamthom T.
Sankyo Company Limited
Shah Mukund J.
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