Benzimidazole derivatives and medical uses thereof

Details Benzimidazole derivatives and medical uses thereof Benzimidazole derivatives and medical uses thereof

2006-06-23

2009-06-16

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S042000

Reexamination Certificate

active

07547680

ABSTRACT:
The present invention provides benzimidazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an inhibitory activity on sodium-dependent nucleoside transporter 2 and are useful for a disease associated with an abnormality of plasma uric acid level. The compounds of the present invention are useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like.In the formula, n is 1 or 2; R1and R2are H, a halogen atom, cyano group, optionally substituted alkyl group, optionally substituted aryl group or the like; R3is H, a halogen atom, optionally substituted alkyl group or the like; R4and R5are H, a halogen atom, OH or the like; and R6and RXare H or OH: RYis F or OH.

REFERENCES:
patent: 6307043 (2001-10-01), Chamberlain et al.
patent: WO 97/25337 (1997-07-01), None
N. Zollner, “Purine and pyrimidine metabolism”, Proc.Nutr.Soc., vol. 41, (1982), pp. 329 to 342.
Mabel W.L. Ritzel, et al., “Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+ -Nucleoside Contransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib)”, J. Biol. Chem., vol. 276, (2001), pp. 2914 to 2927.

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