Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-07-15
1989-12-12
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514269, 514272, 514274, 514275, 514309, 514310, 514312, 514313, 514338, 514359, 514367, 514395, 544238, 544295, 544310, 544317, 544321, 544328, 544331, 544357, 544363, 544364, 544365, 544370, 544495, 546141, 546142, 546143, 546153, 546155, 546157, 546162, 546271, 548159, 548255, 548265, 548268, 548303, A61K 31505, C07D40314
Patent
active
048868035
ABSTRACT:
Compounds are described of formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an alkoxy group, a dialkylamino group or a halogen atom; n is 1 to 4; R.sup.2 is a hydrogen atom, an alkyl group, an unsubstituted or substituted aminoalkyl group, an acyl group, an unsubstituted or substituted aralkyl group, a carboxyalkyl group, an alkoxycarbonyalkyl group or ##STR2## wherein X is an unsubstituted or substituted-phenyl, -benzyl, -benzoyl or -furoyl group; A is -NR.sup.3 - where R.sup.3 is hydrogen or alkyl, an alkylene or an alkylidene; and B is a heterocyclic group selected from triazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzimidazolyl, benzothiazolyl, quinolyl and isoquinolyl, said heterocyclic group being optionally substituted by one or more alkyl, alkoxy, nitro or phenyl group, and the physiologically acceptable acid addition salts thereof. The compound of formula (I) are or cardiotonic activity and thus may be useful for the treatment of circulatory diseases.
REFERENCES:
patent: 4634704 (1987-01-01), Janssens et al.
Petyunin, et al., (I) "Chemical Abstracts", vol. 97, 1982, Col. 97:92201v.
Petyunin, et al. (II), "Chemical Abstracts," vol. 101, 1984, Col. 101:122559p.
Sueda, et al., "Chemical Abstracts," vol. 108, 1988, Col. 108:167472r.
Sueda Noriyoshi
Sugai Toshiji
Suzuki Yoshikuni
Yamada Hiroaki
Yanai Makoto
Hollrah Glennon H.
Nisshin Flour Milling Co. Ltd.
Turnipseed James H.
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