Benzimidazole derivative compounds and method of making

Details Benzimidazole derivative compounds and method of making Benzimidazole derivative compounds and method of making

1988-07-21

1990-08-21

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 546271, 546193, 540597, C07D40104, A61K 3144

Patent

active

049506773

ABSTRACT:
A compound of the formula ##STR1## wherein R.sup.1 -R.sup.19 are as described in the specification. The present invention is concerned with benzimidazole derivatives, particularly benzimidazole-2-yl pyridinium compounds of formula I which are pharmaceutically useful in treating or preventing gastric and duodenal ulcers. The invention includes the compounds I, pharmaceutical compositions containing such compounds and the use of such compounds in therapeutic treatment or prevention of gastric and duodenal ulcers.

REFERENCES:
patent: 4689331 (1987-08-01), Ankner et al.
patent: 4766133 (1988-08-01), Fischli et al.
Derwent No. 86-132721/21 corresponds to U.S. Pat. No. 4,689,331.
Journal of Medicinal Chemistry, vol. 29, 1327-1329 (1986).

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