Benzimidazole derivative compositions and medical use thereof

Details Benzimidazole derivative compositions and medical use thereof Benzimidazole derivative compositions and medical use thereof

1993-05-10

1995-03-28

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548253, C07D4031, A61K 31415

Patent

active

054017645

ABSTRACT:
1-Acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.

REFERENCES:
patent: 4526896 (1985-07-01), Schevrel et al.
patent: 4764623 (1988-08-01), Kees
patent: 4775679 (1988-06-01), Chang
patent: 4880804 (1989-11-01), Carini et al.

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