Benzimidazole derivative and use as a II receptor antagonist

Details Benzimidazole derivative and use as a II receptor antagonist Benzimidazole derivative and use as a II receptor antagonist

2006-08-23

2009-08-11

Anderson, Rebecca L (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S364000

Reexamination Certificate

active

07572920

ABSTRACT:
The present invention relates to a compound represented by the formula (I)wherein R1is a group represented by the formulawherein R2, R3, R4, R5, R6, R7and R8are each independently a hydrogen atom or a C1-6alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.

REFERENCES:
patent: 5196444 (1993-03-01), Naka et al.
patent: 5243054 (1993-09-01), Naka et al.
patent: 5310929 (1994-05-01), Ardecky et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5583141 (1996-12-01), Naka et al.
patent: 5605919 (1997-02-01), Matsumori
patent: 5610314 (1997-03-01), Cheng et al.
patent: 5616599 (1997-04-01), Yanagisawa et al.
patent: 5646171 (1997-07-01), Yanagisawa et al.
patent: 5736555 (1998-04-01), Naka et al.
patent: 5883111 (1999-03-01), Naka et al.
patent: 6100252 (2000-08-01), Naka et al.
patent: 7157584 (2007-01-01), Kuroita et al.
patent: 2005/0032854 (2005-02-01), Kawahara et al.
patent: 0 520 423 (1992-12-01), None
patent: 520423 (1992-12-01), None
patent: 1 452 176 (2004-09-01), None
patent: 4-364171 (1992-12-01), None
patent: 5-078328 (1993-03-01), None
patent: 5-271228 (1993-10-01), None
patent: WO 03/047573 (2003-12-01), None
Kubo et al., J. Med. Chem. 1993, v36, p. 2343-2349.
Kaplan “Angiotensin II Receptor Antagonists in the Treatment of Hypertension”, American Family Physician, 1999, v60, No. 4.
Ura et al. Immunopharmacology, 1999, v44, p. 153-159.
http://progressreport.cancer.gov/doc.asp?pid=1&did=2005&mid=vcol&chid=21.
K. Kubo, et al., “Nonpeptide Angiotension II Receptor Antagonists. Synthesis and Biological Activity of Benzimidazoles”,J. Med. Chem. (1993), vol. 36, No. 12, pp. 1772-1784.
Wexler, R., et al., “Nonpeptide Angiotensin II Receptor Antagonists: THe Next Generation in Antihypertensive Therapy”,Journal of Medicinal Chemistry, (1996), vol. 39, No. 3, pp. 625-656.

Affiliated with

Also associated with

Rating

Benzimidazole derivative and use as a II receptor antagonist does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazole derivative and use as a II receptor antagonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole derivative and use as a II receptor antagonist will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4062553