Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-01-25
2011-01-25
Havlin, Robert (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S132000
Reexamination Certificate
active
07875637
ABSTRACT:
The present invention relates to a compound represented by the formula (I)wherein R1is a group represented by the formulawherein R2, R3, R4, R5, R6, R7and R8are each independently a hydrogen atom or a C1-6alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.
REFERENCES:
patent: 5196444 (1993-03-01), Naka et al.
patent: 5243054 (1993-09-01), Naka et al.
patent: 5310929 (1994-05-01), Ardecky et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5583141 (1996-12-01), Naka et al.
patent: 5605919 (1997-02-01), Matsumori
patent: 5610314 (1997-03-01), Cheng et al.
patent: 5616599 (1997-04-01), Yanagisawa et al.
patent: 5646171 (1997-07-01), Yanagisawa et al.
patent: 5736555 (1998-04-01), Naka et al.
patent: 5883111 (1999-03-01), Naka et al.
patent: 6100252 (2000-08-01), Naka et al.
patent: 7157584 (2007-01-01), Kuroita et al.
patent: 2005/0032854 (2005-02-01), Kawahara et al.
patent: 0 520 423 (1992-12-01), None
patent: 1 452 176 (2004-09-01), None
patent: 4-364171 (1992-12-01), None
patent: 5-078328 (1993-03-01), None
patent: 5-271228 (1993-10-01), None
patent: WO 03/047573 (2003-12-01), None
Farina et al. (Euro. J. of Pharmacology, (1996), v. 310, p. 185-191).
http://progressreport.cancer.gov/doc.asp?pid=1&did=2005&mid=vcol&chid=21 , Circulatory Problems (Peripheral Vascular Disease) accessed Oct. 22, 2007, Oct. 2002 4 pages.
Kaplan, “Angiotensin II Receptor Antagonists in the Treatment of Hypertension,” American Family Physician, 1999, 60(4):8 pages.
Kubo et al., “Nonpeptide Angiotensin II Receptor Antagonists. Synthesis and Biological Activity of Potential Prodrugs of Benzimidazole-7-carboxylic Acids,” J. Med. Chem., 1993, 36:2343-2349.
Kubo et al., “Nonpeptide Antiogensin II Receptor Antagonists. Synthesis and Biological Activity of Benzimidazoles,” J. Med. Chem., 1993, 36(12):1772-1784.
Ura et al., “The mechanisms of insulin sensitivity improving effects of angiotensin converting enzyme inhibitor,” Immunopharmacology, 1999, 44:153-159.
Wexler et al., “Nonpeptide Antiogensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy,” J. Med. Chem., 1996, 39(3):625-656.
Kuroita Takanobu
Ojima Mami
Sakamoto Hiroki
Foley & Lardner LLP
Havlin Robert
Takeda Pharmaceutical Company Limited
LandOfFree
Benzimidazole derivative and use as a II receptor antagonist does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzimidazole derivative and use as a II receptor antagonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole derivative and use as a II receptor antagonist will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2675649