Benzimidazole compounds

Details Benzimidazole compounds Benzimidazole compounds

1998-02-02

2000-08-08

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483044, 5483104, 5483107, A61K 314184, C07D23508, C07D23512, C07D23518

Patent

active

061002836

ABSTRACT:
Benzimidazole-4-carboxamide compounds (I) which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. In formula (I), R and R' may each be selected independently from hydrogen, alkyl, hydroxyalkyl (e.g. CH.sub.2 CH.sub.2 OH), acyl (e.g. acetyl or benzoyl) or an optionally substituted aryl (e.g. phenyl) or aralkyl (e.g. benzyl or carboxybenzyl) group. R is generally a substituted phenyl group in the most preferred compounds. The compounds may also be used in the form of pharmaceutically acceptable salts or pro-drugs. ##STR1##

REFERENCES:
patent: 3795680 (1974-03-01), Burton et al.
patent: 5216003 (1993-06-01), Vazquez
patent: 5314880 (1994-05-01), Whittaker et al.
patent: 5554632 (1996-09-01), Teuber et al.
patent: 5735973 (1998-04-01), Sasahara et al.
Gilchrist et al., J. Chem. Soc., Perkin Trans. 1 (1979), (9), 2303-7, 1979.
Griffin et al., CA 125:189126, 1996.

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