Benzimidazole anti-inflammatory compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S254060, C514S255030, C514S256000, C514S314000, C514S322000, C514S338000, C514S387000, C544S139000, C544S333000, C544S370000, C544S405000, C546S167000, C546S199000, C546S273700, C548S305100, C548S306100

Reexamination Certificate

active

07056918

ABSTRACT:
The present invention relates to novel triazolo-pyridines of the formula Iwherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said heteroatoms atoms must be nitrogen;R2is selected from the group consisting of hydrogen, (C1–C6)alkyl or other suitable substituents;R3is selected from the group consisting of hydrogen, (C1–C6)alkyl or other suitable substituents;s is an integer from 0–5;to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

REFERENCES:
patent: 5716955 (1998-02-01), Adams et al.
patent: 5716972 (1998-02-01), Adams et al.
patent: 5717100 (1998-02-01), Selnick et al.
patent: 5756499 (1998-05-01), Adams et al.
patent: 5777097 (1998-07-01), Lee et al.
patent: 667560 (1979-06-01), None
patent: 9901449 (1999-01-01), None
patent: 9961440 (1999-12-01), None
patent: 0006563 (2000-02-01), None
patent: 0031065 (2000-06-01), None
patent: 0035911 (2000-06-01), None
patent: 0040243 (2000-07-01), None
patent: 0041698 (2000-07-01), None
patent: 0063204 (2000-10-01), None
Blokhin et al., CA 102:113371, 1985.
Blokhin et al., CA 91:75094, 1979..
Surovtsev et al., CA 91:21212, 1979.
Blokhin et al., CA 90:187811, 1979.
Blokhin et al., CA 90:137048, 1979.
Blokhin et al., CA 89:43246, 1978.
Rozin et al., CA 83:9900, 1975.
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Lee et al., Immunopharmacology, 47 (2000), pp. 185-201.
The Journal of Biological Chemistry, vol. 271, No. 40, pp. 24313-24316 (1996).
Bioorganic & Medicinal Chemistry Letters, 10, pp. 2047-2050 (2000); and.
Bioorganic & Medicinal Chemistry Letters, 11, pp. 9-12 (2001).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Benzimidazole anti-inflammatory compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazole anti-inflammatory compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole anti-inflammatory compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3662852

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.