Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-06
2006-06-06
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S254060, C514S255030, C514S256000, C514S314000, C514S322000, C514S338000, C514S387000, C544S139000, C544S333000, C544S370000, C544S405000, C546S167000, C546S199000, C546S273700, C548S305100, C548S306100
Reexamination Certificate
active
07056918
ABSTRACT:
The present invention relates to novel triazolo-pyridines of the formula Iwherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said heteroatoms atoms must be nitrogen;R2is selected from the group consisting of hydrogen, (C1–C6)alkyl or other suitable substituents;R3is selected from the group consisting of hydrogen, (C1–C6)alkyl or other suitable substituents;s is an integer from 0–5;to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
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Dombroski Mark A.
Letavic Michael A.
McClure Kim F.
Ashbrook Charles
Lappin Julie M.
Pfizer Inc.
Stockton Laura L.
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