Benzimidazole anthelmintic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546144, 548159, 548194, 548204, 548241, 5483047, 5483051, 5483061, 5483087, 5483094, 514307, 514368, 514370, 514373, 514379, A61K 31415, C07D23532, C07D40104, C07D40504

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active

054687659

ABSTRACT:
##STR1## Benzimidazole anthelmintic agents of formula (I) and their non-toxic salts in which R is H, CO.sub.2 (C.sub.1 -C.sub.10 alkyl), --CO.sub.2 (cholester-3-yl) or --CO.sub.2 (CH.sub.2)COOH or --CO.sub.2 (CH.sub.2).sub.n CO.sub.2 (C.sub.1 -C.sub.6 alkyl), n=1 to 10, R.sup.1 is optionally substituted benzoyl, phenyloxy, phenylthio, phenyisulfonyl, phenylsulfinyl, phenylsulfonyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cycloalkylcarbonyl or is selected from a variety of heterocyclic groups and R.sup.2 and R.sup.3 are independently --CO.sub.2 (C.sub.1 -C.sub.4 alkyl).

REFERENCES:
patent: 3915986 (1975-10-01), Gyurik et al.
patent: 4002640 (1977-01-01), Beard et al.
patent: 4435418 (1984-03-01), Chow
patent: 4512998 (1985-04-01), Nafissi-Varchei
patent: 4826841 (1989-05-01), Gajewski
patent: 4826862 (1989-05-01), Raeymaekers et al.

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