Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-09-21
2010-06-08
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S394000
Reexamination Certificate
active
07732618
ABSTRACT:
The invention relates to benzimidazole acetic acid compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells (CRTH2) receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
REFERENCES:
patent: 3590047 (1971-06-01), Shen et al.
patent: 5612360 (1997-03-01), Boyd et al.
patent: 6114532 (2000-09-01), Ries et al.
patent: 6121308 (2000-09-01), Hauel et al.
patent: 6365584 (2002-04-01), Anderskewitz et al.
patent: 62-24244 (1987-02-01), None
patent: 2000-95767 (2000-04-01), None
patent: 2000-143635 (2000-05-01), None
patent: WO 97/10219 (1997-03-01), None
patent: WO 02/060438 (2002-08-01), None
patent: WO 03/101981 (2003-12-01), None
An English translation of Sakamoto et al., JP 62-24244, 1987.
Corrected English translation of Sakamoto et al., JP 62-24244, 1987.
Bohm, E., et al., “11-Dehydro-thromboxane B2, a Stable Thromboxane Metabolite, Is a Full Agonist of Chemoattractant Receptor-homologous Molecule Expressed on TH2 Cells (CRTH2) in Human Eosinophils and Basophils,”J. Biol. Chem. 279:7663-7670, The American Society for Biochemistry and Molecular Biology, Inc. (Feb. 2004).
Boie, Y., et al., “Molecular Cloning and Characterization of the Human Prostanoid DP Receptor,” 270:18910-18916, The American Society for Biochemistry and Molecular Biology, Inc. (1995).
Fujitani, Y., et al., “Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice,”J. Immunol. 168:443-449, The American Association of Immunologists (2002).
Hirai, H., et al., “Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor CRTH2,”J. Exp. Med. 193:255-261, The Rockefeller University Press (2001).
Liu, M.C., et al., “Evidence for Elevated Levels of Histamine, Prostaglandin D2, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma,”Am. Rev. Respir. Dis. 142:126-132, American Lung Association (1990).
Nagata, K., et al., “Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo,”J. Immunol. 162:1278-1286, American Association of Immunologists (1999).
Patent Abstracts of Japan, English language abstract of JP62-024244, 1987.
Patent Abstracts of Japan, English language abstract of JP2000-095767, 2000.
Patent Abstracts of Japan, English language abstract of JP2000-143635, 2000.
International Search Report for PCT Application No. PCT/US2005/034028 dated Mar. 23, 2006.
International Search Report for corresponding PCT Application No. PCT/US2005/034029 dated Apr. 27, 2007.
Bennani Youssef L.
Gleason Elizabeth Ann
Robarge Michael Joseph
Tumey Lawrence Nathan
Finnegan Henderson Farabow Garrett & Dunner LLP
Stockton Laura L.
Wyeth
LandOfFree
Benzimidazole acetic acids exhibiting CRTH2 receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzimidazole acetic acids exhibiting CRTH2 receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole acetic acids exhibiting CRTH2 receptor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4209964