Benzimidazol-2-one derivatives and their use

Details Benzimidazol-2-one derivatives and their use Benzimidazol-2-one derivatives and their use

2007-07-17

2007-07-17

Stockton, Laura L. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S306400

Reexamination Certificate

active

10518554

ABSTRACT:
Certain 1,5-disubstituted benzimidazol-2-one compounds useful as therapeutic agents. The compounds may be of the Formula Iwherein: R′ represents hydrogen or alkyl; R″ represents halogen or trihalogenmethyl; and Hlg represents halogen; provided, however, that if Hlg is F, then R″ is not Cl. Also, use of the 1,5-disubstituted benzimidazol-2-one compounds, or pharmaceutically-acceptable addition salts thereof, in applications that benefit from increasing the blood-brain barrier permeability.

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Ramnarine et al., “Neuroregulation of Mucus Secretion by Opioid Receptors and KATP and BKCA Channels in Ferret Trachea in vitro”, British Journal of Pharmacology (1998) 123, 1631-1638.

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