Benzhydrylamine derivatives

Details Benzhydrylamine derivatives Benzhydrylamine derivatives

1990-05-24

1991-09-24

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

530309, 530315, 530334, 562441, C07C27122

Patent

active

050515268

ABSTRACT:
Novel benzhydrylamine derivatives represented by general formulas (I) and (II) are useful as reaction reagents for the solid-phase synthesis of polypeptide amides making use of 9-fluorenylmethyloxycarbonyl group ("Fmoc"). An intermediate for these derivatives represented by the general formula (III) is also disclosed: ##STR1## where R.sub.1 and R.sub.2 each independently represents a C.sub.1-3 lower alkyl; n is an integer of 1-4; l is 1 or 2; and m is 1 or 2.

REFERENCES:
Oe et al., Chemical Abstracts, vol. 81, 120462w, (1974).
Albericio et al., Internat'l Journal of Peptide & Protein Res., vol. 30, 1987, pp. 206-216.
Funakoshi et al., Journal of the Chemical Soc., Chem. Commun., vol. 5, Mar. 1, 1988, pp. 382-384.

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