Benzhydryl derivatives having calmodulin inhibitor properties

Details Benzhydryl derivatives having calmodulin inhibitor properties Benzhydryl derivatives having calmodulin inhibitor properties

1991-07-19

1992-12-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564317, A61K 31135, C07C32326

Patent

active

051717522

ABSTRACT:
The invention relates to a benzhydryl derivative having the formula ##STR1## wherein each of the groups R.sub.1, R.sub.2, and R.sub.3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF.sub.3, and at least one of the groups R.sub.1, R.sub.2, and R.sub.3 is halogen or CF.sub.3 ;

REFERENCES:
patent: 3666811 (1972-05-01), van der Stelt
N. V. Koninklyke, Chemical Abstracts, vol. 72 (1970) 1002684.
Corsano et al., Chemical Abstracts, vol. 112 (1989) 118353b.
Kansal et al., "Possible antihypertensive agents: Synthesis of N-aralkyl-beta Substituted Phenylethylamines and N-alkyl/acyl-6,7-dimethoxy-1-[alpha-phenyl-beta-substituted phenyl)ethyl]-1,2,3,4-tetrahydroisoquinolines", Chemical Abstracts, vol. 96, No. 9, Mar. 1, 1982, p. 592, Abstract No. 68781t, U.S.A.
Barron et al., D. I., "Compounds Affecting the Central Nervous System. III. Substituted 1,1-Diaryl-t-aminopropanols and Related Compounds", Journal of Med. Chemistry, vol. 8, Nov. 1985, pp. 836-841, U.S.A.
Gualtieri, F. et al., "SAR Studies in the Field of Calcium(II) Antagonists. Effect of Modifications at the Tetrasubstituted Carbon of Verapamil-like Compounds", Journal of Medicinal Chemistry, vol. 28, No. 11, pp. 1621-1628, U.S.A., 1985.
Zenno et al., "Tertiary bis(phenylalkyl)amines", Chemical Abstracts, vol. 82, No. 7, Feb. 17, 1975, p. 406, No. 430412, U.S.A.

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