Benzenetricarboxylate derivative-crosslinked low oxygen affinity

Details Benzenetricarboxylate derivative-crosslinked low oxygen affinity Benzenetricarboxylate derivative-crosslinked low oxygen affinity

1991-08-15

1994-08-02

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530410, A61K 3700, A61K 3514, A61K 3702, C07K 1300

Patent

active

053347056

ABSTRACT:
The invention is directed to a low oxygen affinity stroma-free tetrameric mammalian hemoglobin which is produced by crosslinkng with a derivative of benzenetricarboxylate, as well as methods for its preparation. Crosslinked stroma-free hemoglobin produced by methods of the present invention may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or as in a plasma expander.

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