Benzenesulfonyl-chromane, thiochromane,...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S455000

Reexamination Certificate

active

08067621

ABSTRACT:
This invention discloses novel gamma secretase inhibitors of the formula:R2and R3, or R2and R4, or R3and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substitutents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.

REFERENCES:
patent: 1 586 561 (2005-10-01), None
patent: WO 00/50391 (2000-08-01), None
patent: WO 03/014075 (2003-02-01), None
patent: WO 2004/031137 (2004-04-01), None
patent: WO 2004/101539 (2004-11-01), None
patent: WO 2006/004880 (2006-01-01), None
patent: WO 2007/084595 (2007-07-01), None
patent: WO 2007/143523 (2007-12-01), None
patent: WO 2009/008980 (2009-01-01), None
McCombie, S,W., et al., “A Cyclization-Trapping Route to Carbocyclic and Heterocyclic Benzylic Sulfones,” Tetrahedron Letters, vol. 34, No. 50, pp. 8033-8036 (1993).
PCT International Search Report dated Jul. 13, 2007, for corresponding PCT Application No. PCT/US2007/001302.
International Search Report for International Application No. PCT/US2008/008192 mailed on Jan. 28, 2009; 5 pages.
Written Opinion for International Application No. PCT/US2008/008192; 8 pages.

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