Benzenesulfon YL-semicarbazides for lowering blood sugar levels

Details Benzenesulfon YL-semicarbazides for lowering blood sugar levels Benzenesulfon YL-semicarbazides for lowering blood sugar levels

1973-01-18

1976-02-17

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61k 2700

Patent

active

039392694

ABSTRACT:
Hypoglycemically active benzenesulfonyl-semicarbazides of the formula ##SPC1##
Wherein X is hydrogen, chlorine, bromine, methyl or methoxy, Y is --CH(CH.sub.3)-CH.sub.2 --, preferably --CH.sub.2 --CH.sub.2 --, Z is hydrogen or a hydrocarbon radical of 1 or 2 carbon atoms, which forms together with Y a 5- or 6-membered ring, R is alkylene-imino of 3 to 7 carbon atoms in the ring which may be unsaturated or substituted by 1 or 2 methyl or lower alkyl or methoxy, pentamethylene-imino substituted by endoalkylene of 1 to 3 carbon atoms, hexamethylene-imino substituted by endoethylene in .beta.- .epsilon.-position, tetrahydro-iso-indoline, 4,7-endoalkylenehexahydro- or -tetrahydro-iso-indoline, the endoalkylene containing 1 or 2 carbon atoms and the double bond of the tetrahydro compound being in 5,6-position, and the salts thereof as pharmaceutical preparations for oral administration and lowering of blood sugar level in the treatment of diabetes mellitus and the process for lowering the blood sugar level in the treatment of diabetes mellitus.

REFERENCES:
patent: 3041331 (1962-06-01), Wright
patent: 3239503 (1966-03-01), Kovgeu et al.
patent: 3549645 (1970-12-01), Heerdt et al.
patent: 3655756 (1972-04-01), Weber et al.
ambrogi et al., Avzneim-Forsch 1971, Vol. 21, pp. 200-207. 207.
Kuvzcr, Chem. Reviews Vol. 50, p. 27, (1952).

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