Benzene derivatives having NGF production-promoting activity

Details Benzene derivatives having NGF production-promoting activity Benzene derivatives having NGF production-promoting activity

1995-04-24

1997-03-25

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514331, 514443, 514617, 514626, 544162, 544163, 544166, 546192, 549 57, 564155, 564157, 564158, A61K 31535, C07C23300, C07D26530

Patent

active

056145217

ABSTRACT:
A compound of the formula (I): ##STR1## wherein R.sup.1 is an unsubstituted or substituted amino group, a protected amino group, or a nitro group; R.sup.2 is an unsubstituted or substituted amino group, a protected amino group, an unsubstituted or substituted hydroxy group or a protected hydroxy group; R.sup.3 is an unsubstituted or substituted amino group, m is 0 to 2; n is 0 to 6; with the proviso that when m is 0, then n is an integer from 2 to 6, and pharmaceutically acceptable salts thereof. Compounds of formula (I) except those wherein R.sup.1 is a nitro group have activity in promoting the production of nerve growth factor.

REFERENCES:
patent: 3147261 (1964-09-01), Mod et al.
patent: 3539578 (1970-11-01), Brown
Chemical Abstracts, vol. 105, No. 13, 29 Sep. 1986, Columbus, Ohio, US; Abstract No. 115063b, M.H. Hockley, R.B. Titman "Therapeutic agents" of EP-A-0 172 631.
Patent Abstracts of Japan, vol. 14, No. 310 (C-736) (4253), 4 Jul. 1990 of JP-A-02 104 568.
Lenz et al., Biol. Chem. Hoppe-Seyler, 372, 495-504, Jul. 1991.
Chemical Abstract vol. 115 No. 270827, Lenz et al, "Semisynthetic des(B27-B30)-Insulins with Modified B26-Tyrosine" (1991).

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