Benzene derivatives having NGF production-promoting activity

Details Benzene derivatives having NGF production-promoting activity Benzene derivatives having NGF production-promoting activity

1992-02-18

1997-07-01

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546162, 546171, 514313, A01N 4342, C07D21538, C07D21514

Patent

active

056439253

ABSTRACT:
Novel benzene derivatives are provided of the general formula (I): ##STR1## [wherein R.sup.1 represents an amino group, a substituted amino group, a protected amino group, or a nitro group; R.sup.2 represents an amino group, a substituted amino group, a protected amino group, a hydroxy group, a substituted hydroxy group, or a protected hydroxy group; R.sup.3 represents an amino group, a substituted amino, a heterocyclyl group having a ring nitrogen atom as the point of binding, or a substituted heterocyclyl group having a ring nitrogen atom as the point of binding; m is 0 to 2; n is 0 to 6; with the proviso that when m is 0, then n represents an integer from 2 to 6] and salts thereof.
Compounds of formula (I) except those wherein R.sup.1 is a nitro group have activity in promoting production of nerve growth factor. Compounds of formula (I) wherein R.sup.1 is a nitro group are intermediates for compounds of formula (I) wherein R.sup.1 is an amino group.

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Chemical Abstracts, vol. 115, No. 270827 (1991).
Lenz et al., Biol. Chem. Hoppe-Seyler, 372, 495-504, Jul. 1991.
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Patent Abstracts of Japan, vol. 14, No. 310 (C-736) (4253), 4 Jul. 1990 of JP-A-02 104 568.

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