Benzazolylcoumarin-based ion indicators for heavy metals

Details Benzazolylcoumarin-based ion indicators for heavy metals Benzazolylcoumarin-based ion indicators for heavy metals

1994-05-20

1995-10-17

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

436 74, 436800, 548217, 5483047, G01N 3352, C07D41704, C07D40704

Patent

active

054592763

ABSTRACT:
The indicator compounds of the present invention are substituted or unsubstituted 5'-nitro-BAPTA chelators that contain a benzazolyl-coumarin substructure, and the pharmaceutically acceptable non-toxic salts and esters thereof. These compounds are useful for the detection and quantification of polycationic metal ions, particularly Zn.sup.2+, Pb.sup.2+, Ba.sup.2+, Cd.sup.2+, Hg.sup.2+ and La.sup.3+.
The compounds of the invention have the structure: ##STR1## where m=2 or 3 and X can be S, O, or C(CH.sub.3).sub.2 ; optionally substituted by substituents that alter the binding affinity of the indicator, shift the spectral properties of the indicator, or act as a reactive site for the preparation of a variety of conjugates.

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