Benzazole derivatives, compositions, and methods of use as...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S307000

Reexamination Certificate

active

07893267

ABSTRACT:
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

REFERENCES:
patent: 3336191 (1967-08-01), Craig et al.
patent: 3401173 (1968-09-01), Chow et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5942400 (1999-08-01), Anderson et al.
patent: 5998398 (1999-12-01), Daluge et al.
patent: 6207693 (2001-03-01), Setoi et al.
patent: 6303600 (2001-10-01), Cox et al.
patent: 6329163 (2001-12-01), Anderson et al.
patent: 6353010 (2002-03-01), Dyke et al.
patent: 6420534 (2002-07-01), Gurney et al.
patent: 6440698 (2002-08-01), Gurney et al.
patent: 6448271 (2002-09-01), Lubisch et al.
patent: 6489328 (2002-12-01), Snow et al.
patent: 6506769 (2003-01-01), Snow et al.
patent: 6545127 (2003-04-01), Tang et al.
patent: 6562783 (2003-05-01), Qiao et al.
patent: 6610734 (2003-08-01), Kreft et al.
patent: 6627409 (2003-09-01), Hook
patent: 6627739 (2003-09-01), Anderson et al.
patent: 6660741 (2003-12-01), Bornmann et al.
patent: 6696437 (2004-02-01), Lubisch et al.
patent: 6699671 (2004-03-01), Gurney et al.
patent: 6706485 (2004-03-01), Gurney et al.
patent: 6706742 (2004-03-01), De Nanteuil et al.
patent: 6713276 (2004-03-01), Cordell et al.
patent: 6727074 (2004-04-01), Gurney et al.
patent: 6737510 (2004-05-01), Gurney et al.
patent: 6753163 (2004-06-01), Gurney et al.
patent: 6790610 (2004-09-01), Gurney et al.
patent: 6825023 (2004-11-01), Gurney et al.
patent: 6825219 (2004-11-01), Cywin et al.
patent: 6828117 (2004-12-01), Gurney et al.
patent: 6835565 (2004-12-01), Gurney et al.
patent: 2002/0055459 (2002-05-01), Chopra et al.
patent: 2002/0081634 (2002-06-01), Gurney et al.
patent: 2002/0115616 (2002-08-01), Boyd et al.
patent: 2002/0123484 (2002-09-01), Das et al.
patent: 2002/0128255 (2002-09-01), Beck et al.
patent: 2002/0143177 (2002-10-01), Beck et al.
patent: 2002/0157122 (2002-10-01), Wong et al.
patent: 2002/0159991 (2002-10-01), Cordell et al.
patent: 2002/0187928 (2002-12-01), Qiao et al.
patent: 2002/0194632 (2002-12-01), McConlogue et al.
patent: 2003/0083356 (2003-05-01), Schostarez et al.
patent: 2003/0092003 (2003-05-01), Blatt et al.
patent: 2003/0095958 (2003-05-01), Bhisetti et al.
patent: 2003/0097004 (2003-05-01), Taveras et al.
patent: 2003/0109559 (2003-06-01), Gailunas et al.
patent: 2003/0125257 (2003-07-01), Brockhaus et al.
patent: 2003/0134854 (2003-07-01), Flohr et al.
patent: 2003/0143708 (2003-07-01), Blatt et al.
patent: 2003/0144286 (2003-07-01), Frenkel et al.
patent: 2003/0167486 (2003-09-01), Jacobsen et al.
patent: 2004/0005691 (2004-01-01), Chou et al.
patent: 2004/0006119 (2004-01-01), Lang et al.
patent: 2004/0014194 (2004-01-01), Beyer et al.
patent: 2004/0034078 (2004-02-01), Skalitzky et al.
patent: 2004/0063645 (2004-04-01), Botyanszki et al.
patent: 2004/0097547 (2004-05-01), Taveras et al.
patent: 2004/0110743 (2004-06-01), Miyamato et al.
patent: 2004/0110808 (2004-06-01), Strobe et al.
patent: 2004/0146953 (2004-07-01), Blackstock et al.
patent: 2004/0147454 (2004-07-01), Yang
patent: 2004/0171881 (2004-09-01), John et al.
patent: 2004/0180939 (2004-09-01), John et al.
patent: 2004/0209925 (2004-10-01), Pulley et al.
patent: 2004/0214846 (2004-10-01), Hom et al.
patent: 2004/0214890 (2004-10-01), Fobian et al.
patent: 2004/0234976 (2004-11-01), Gurney et al.
patent: 2004/0241792 (2004-12-01), Yan et al.
patent: 2004/0248232 (2004-12-01), Hook
patent: 2004/0253245 (2004-12-01), Briend et al.
patent: 2004/0253706 (2004-12-01), Yan et al.
patent: 2004/0254213 (2004-12-01), Beck
patent: 2004/0254341 (2004-12-01), Yan et al.
patent: 2004/0254342 (2004-12-01), Yan et al.
patent: 2004/0266871 (2004-12-01), Schostarez et al.
patent: 2005/0049263 (2005-03-01), Kasibhatla et al.
patent: 2005/0176792 (2005-08-01), Moriarty et al.
patent: 2005/0203146 (2005-09-01), Herpin et al.
patent: 2006/0223849 (2006-10-01), Mjalli et al.
patent: 2007/0219235 (2007-09-01), Mjalli et al.
patent: 1 502 916 (2005-02-01), None
patent: 1122957 (1968-08-01), None
patent: WO 98-24771 (1998-06-01), None
patent: WO 98/24771 (1998-06-01), None
patent: WO 01-00611 (2001-01-01), None
patent: WO 01-21615 (2001-03-01), None
patent: WO 01-25238 (2001-04-01), None
patent: WO 02-14319 (2002-02-01), None
patent: WO 02-069965 (2002-09-01), None
patent: WO 03-032984 (2003-04-01), None
patent: WO 03/041708 (2003-05-01), None
patent: WO 03-041708 (2003-05-01), None
patent: WO 03-053939 (2003-07-01), None
patent: WO 03-075921 (2003-09-01), None
patent: WO 03-087089 (2003-10-01), None
patent: WO 03-105846 (2003-12-01), None
patent: WO 2004-014369 (2004-02-01), None
patent: WO 2004-043916 (2004-05-01), None
patent: WO 2004-050619 (2004-06-01), None
patent: WO 2004-054974 (2004-07-01), None
patent: WO 2004-062625 (2004-07-01), None
patent: WO 2005-044793 (2005-05-01), None
patent: WO 2005-108399 (2005-11-01), None
patent: WO 2005-112932 (2005-12-01), None
Agarwal et al., “Segregation of Activity Profile in Benzimidazoles: Effect of Spacers at 5(6)-Position of Methyl Benzimidazole-2-Carbamates” Journal of Biosciences, vol. 48, pp. 823-838 (1993).
Andrau et al., “BACE1-and BACE2-Expressing Human Cells” The Journal of Biological Chemistry, vol. 278, pp. 25859-25866 (2003).
Asai et al., “Putative Function of ADAM9, ADAM10, and ADAM17 as APP α-Secretase” Biochemical and Biophysical Research Communications, vol. 301, pp. 231-235 (2003).
Citron et al., “β-Secretase Inhibition for the Treatment of Alzheimer's Disease Promise and Challenge” TRENDS in Pharmacological Sciences, vol. 25, pp. 92-97 (2004).
Colciaghi et al., “Platelet APP, ADAM 10 and BACE Alterations in the Early Stages of Alzheimer Disease” Neurology, vol. 62, pp. 498-501 (2004).
De Strooper et al., “A Firm Base for Drug Development” Nature, vol. 402, pp. 471-472 (1999).
Dingwall et al., “Spotlight on BACE: The Secretases as Targets for treatment in Alzheimer Disease” The Journal of Clinical Investigation, vol. 108, pp. 1243-1246 (2001).
Elliott et al., “Structure—Activity Relationship Studies on 2-Heteroaryl-4-arylimidazoles NPY5 Receptor Antagonists” Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 3593-3596 (2003).
Eriksen et al., “NSAIDs and Enantiomers of Flurbiprofen Target v-Secretase and Lower Aβ42 in Vivo” The Journal of Clinical Investigation, vol. 112, pp. 440-449 (2003).
Fukumoto et al., “β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain” American Journal of Pathology, vol. 164, pp. 719-725 (2004).
Greeve et al., “The Human DIMINUTO/DWARF1 Homolog Seladin-1 Confers Resistance to Alzheimer's Disease-Associated Neurodegeneration and Oxidative Stress” The Journal of Neuroscience, vol. 20, pp. 7345-7352 (2000).
Grüninger-Leitch et al., “Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases” The Journal of Biological Chemistry, vol. 277, pp. 4687-4693 (2002).
Haass et al., “Take Five—BACE and thev-Secretase Quartet Conduct Alzheimer's Amyloid β-Peptide Generation” The European Molecular Biology Organization Journal, vol. 23, pp. 483-488 (2004).
Haniu et al., “Characterization of Alzheimer's β-Secretase Protein BACE” The Journal of Biological Chemistry, vol. 275, pp. 21099-21106 (2000).
Kajkowski et al., “β Amyloid Peptide-Induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module” The Journal of Biological Chemistry, vol. 276, pp. 18748-18756 (2001).
Kamenetz et al., “APP Processing and Synaptic Function”

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