Benzazole derivatives and their use as JNK modulators

Details Benzazole derivatives and their use as JNK modulators Benzazole derivatives and their use as JNK modulators

2007-08-21

2007-08-21

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252110, C514S252140, C514S256000, C514S274000, C544S122000, C544S295000, C544S296000, C544S310000, C544S315000, C544S333000

Reexamination Certificate

active

10168718

ABSTRACT:
The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation.X is O, S or NR0, with R0being H or an unsubstituted or substituted C1-C6alkyl;G is an unsubstituted or substituted pyrimidinyl group.

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