Benzazocinone and benzazoninone derivatives, and their pharmaceu

Details Benzazocinone and benzazoninone derivatives, and their pharmaceu Benzazocinone and benzazoninone derivatives, and their pharmaceu

1983-02-10

1984-09-11

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424244, 424267, 424274, 2602393B, 2602393T, A61K 3155, C07D22316

Patent

active

044709889

ABSTRACT:
Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-benzazocin-2-one and benzazonin-2-one derivatives are disclosed as angiotensin converting enzyme inhibitors and antihypertensive agents. Synthesis of, pharmaceutical compositions and methods of treatment utilizing such compounds are included.

REFERENCES:
patent: 3661927 (1972-05-01), Zivkovic
patent: 3748321 (1973-07-01), Krapcho, Jr.
patent: 4322439 (1982-03-01), Klemm et al.
patent: 4410520 (1983-10-01), Watthey
Saike, I., "J. Am. Chem. Society", vol. 1, pp. 7332-7338, (1979).
Biochemical and Biophysical Research Communications, Nov. 30, 1983, Parsons et al., vol. 117, pp. 108-113.

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