Benzazine compounds and pharmaceutical uses thereof

Details Benzazine compounds and pharmaceutical uses thereof Benzazine compounds and pharmaceutical uses thereof

1991-06-26

1993-02-09

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142305, 544 52, 544105, 544 73, A61K 3154, A61K 31535, C07D27916, C07D26536

Patent

active

051853337

ABSTRACT:
A benzazine compound, a geometrical isomer of said benzazine compound, an optical isomer of said benzazine compound, and a pharmaceutically acceptable salt of said benzazine compound, said benzazine compound being represented by formula (I): ##STR1## wherein each symbol is as defined in the specification. Said benzazine compounds exhibit 5-HT.sub.3 receptor antagonistic activity, and 5-HT.sub.1A receptor and/or 5-HT.sub.2 receptor and/or dopamine D.sub.2 receptor blocking activity so that they are useful as drugs for the prophylaxis or treatment of various digestive diseases vomiting and disturbances in central nervous systems and the like. The intermediates for said benzazine compounds are also disclosed.

REFERENCES:
patent: 4778792 (1988-10-01), Lesieur et al.
patent: 4826839 (1989-05-01), King et al.
patent: 4892872 (1990-01-01), Tahara et al.
patent: 4933445 (1990-06-01), Pelletier et al.
patent: 4935511 (1990-06-01), Youssefyeh et al.
patent: 4937337 (1990-06-01), Leinert et al.

Affiliated with

Also associated with

Rating

Benzazine compounds and pharmaceutical uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzazine compounds and pharmaceutical uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzazine compounds and pharmaceutical uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-325716