Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-30
2005-08-30
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S081000, C514S086000, C514S220000, C514S230500, C514S253010, C514S253090, C514S255050, C514S263230, C514S263400, C514S274000, C514S307000, C514S314000, C514S365000, C514S471000, C540S495000, C540S593000, C544S092000, C544S243000, C544S244000, C544S265000, C544S277000, C544S312000, C544S314000, C544S317000, C544S336000, C544S360000, C544S364000, C546S146000, C546S169000, C548S204000
Reexamination Certificate
active
06936602
ABSTRACT:
Compounds of the general formula (I):or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1and Z2are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2and R3are each optionally substituted aliphatic hydrocarbyl or an optionally Substituted hetero-alicyclic group.
REFERENCES:
patent: 5716944 (1998-02-01), Sohda et al.
patent: 6166006 (2000-12-01), Shiraishi et al.
patent: 6172061 (2001-01-01), Nishimura et al.
patent: 0 825 186 (1998-02-01), None
patent: 7025756 (1995-01-01), None
patent: 7025757 (1995-01-01), None
patent: WO 96/01267 (1996-01-01), None
patent: WO 99/32100 (1999-07-01), None
patent: WO 99/32468 (1999-07-01), None
patent: WO 00/10965 (2000-03-01), None
patent: WO 00/37455 (2000-06-01), None
patent: WO 00/68203 (2000-11-01), None
HORUK, Chemokine Receptors, Cytokine and Growth Factor Reviews, Dec. 2001, vol. 12, No. 4, pp. 313-335.
M. Baba et al. “A Small-Molecule, Nonpeptide CCR5 Antagonist with Highly Potent and Selective Anti-HIV-I Activity”, Proc. Natl. Acad. Sci USA (May 1999) vol. 96, pp. 5698-5703.
Aramaki Yoshio
Baba Masanori
Kanzaki Naoyuki
Nishimura Osamu
Shiraishi Mitsuru
Chao Mark
Coleman Brenda
Ramesh Elaine M.
Takeda Chemical Industries Ltd.
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