Benzazabicyclic carbamates as novel cholinesterase inhibitors

Details Benzazabicyclic carbamates as novel cholinesterase inhibitors Benzazabicyclic carbamates as novel cholinesterase inhibitors

1994-10-25

1997-01-14

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 97, C07D22122, A61K 31445

Patent

active

055940021

ABSTRACT:
##STR1## Compounds of formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, m, n, o, p, q and r are as defined below. The compounds are memory enhancing cholinesterase inhibitors useful in enhancing memory, novel intermediates used in their synthesis, and analgesic agents.

REFERENCES:
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Druckarach et al., Life Science, 42, 1001 (1988);.
Summers et al., New England Journal of Medicine, 315, 1241 (1986);.
Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th Ed., Pergamon Press, pp. 147 and 489-490.
Arthur E. Jacobson and Michael Mokotoff, Azabicyclo Chemistry I. Synthesis of 1.5-Methano-7-methoxy-2,3,4,5-tetrahydro-III-2-benzazepines. B-Norbenzomorphans, J. Chem. Soc., (13) 7-9 (1970).
Yokoyama et al., J. Med. Chem., 22, 537 (1979).

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