Benzamidoxime prodrugs as antipneumocystic agents

Details Benzamidoxime prodrugs as antipneumocystic agents Benzamidoxime prodrugs as antipneumocystic agents

1998-07-31

2000-02-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564229, A61K 3115

Patent

active

060253983

ABSTRACT:
A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P. carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.

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