Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-09-09
2000-06-06
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544219, 544216, 544197, 544194, 544180, A61K 3153, C07D25126
Patent
active
060719125
ABSTRACT:
This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
REFERENCES:
patent: 4064169 (1977-12-01), Hamano et al.
patent: 5332822 (1994-07-01), Misra
patent: 5451700 (1995-09-01), Morrissey et al.
patent: 5612363 (1997-03-01), Mohan et al.
patent: 5633381 (1997-05-01), Dallas et al.
patent: 5691364 (1997-11-01), Buckman et al.
patent: 5693641 (1997-12-01), Buckman et al.
patent: 5726173 (1998-03-01), Mohan et al.
patent: 5726198 (1998-03-01), Mohan et al.
patent: 5728697 (1998-03-01), Mohan et al.
patent: 5731308 (1998-03-01), Mohan et al.
patent: 5731311 (1998-03-01), Mohan et al.
patent: 5753635 (1998-05-01), Buckman et al.
patent: 5846970 (1998-12-01), Buckman et al.
patent: 5846972 (1998-12-01), Buckman et al.
patent: 5849759 (1998-12-01), Arnaiz et al.
patent: 5859005 (1999-01-01), Mohan et al.
patent: 5863914 (1999-01-01), Mohan et al.
patent: 5877181 (1999-03-01), Buckman et al.
patent: 5883100 (1999-03-01), Buckman et al.
patent: 5889005 (1999-03-01), Buckman et al.
Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombosis Research, (1980) 19:339-349.
Wagner, G. et al., "Synthese von a-a'-Bis[amidinobenzyliden]-und a-a'Bis-[amidinobenzyl]-cycloalkanonen," Pharmazie, (1977) 32, 141-145.
Sturzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylanmioacylated 4-amidinophenylalanine--Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by (2R,4R)-4-Methyl-1-[N.sup.2 -[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-sulfonyl]-L-arginyl)]-2piperi dinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545:548.
Chauhan , P. et al., "Effect of new diamidines against Leishmania donovani infection," Indian Journal of Experimental Biology, (1993) 31:196-198.
Ashley, J. et al., "The Search for Chemotherapeutic Amidines. Part XVI. Amidinoanilino-1,3,5-triazines and Related Compounds", J. of the Chemical Society, (1960) 4525:4532.
Geratz, J. et al., "The Inhibition of Urokinase by Aromatic Diamidines" Thrombos. Diathes haemorrh. (Stuttg.), (1975)33:230-243.
Geratz, J. et al. "Novel Bis (benzamidino) Compounds with an Aromatic Central Link. Inhibitors of Thrombin, Pancreatic Kallikrein, Trypsin, and Complement" J. of Medicinal Chemistry, (1976) 19(5):634-639.
Chauhan, P. et al., "Antiparasitic Agents: Part VI--Synthesis of 1,2-,1,3-&1,4-Bis(4-substituted aryloxy)benzenes & Their Biological Activities", Indian Journal of Chemistry, (1988) 27B:38-42.
U.S. Pat. application Ser. No. 09/205,498, filed Dec. 4, 1998, entitled: Aryl Substituted N-Heterocyclic Derivatives as Anti-Coagulants.
U.S. Pat. application Ser. No. 09/187,459, filed Nov. 5, 1998, entitled: Ortho-Anthranilamide Derivatives as Anti-Coagulants.
U.S. Pat. application Ser. No. 09/196,921, filed Nov. 19, 1998, entitled: Polyhydroxylated Monocyclic N-Heterocyclic Derivatives as Anti-Coagulants.
U.S. Pat. application Ser. No. 08/920,319, filed Aug. 27, 1997, entitled: Benzamidine Derivatives Substituted by Cyclic Amino Acid and Cyclic Hydroxy Acid Derivatives and Their Use as Anti-Coagulants.
Kochanny Monica
Mohan Raju
Morrissey Michael M.
Ng Howard P.
Yun Weiya
Aulakh Charanjit S.
Berlex Laboratories Inc.
Kight John
Roth Carol J.
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