Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-02-12
1999-11-30
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462751, 546296, 544333, A61K 3144, C07D40110
Patent
active
059943750
ABSTRACT:
This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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Chauhan, P. et al., "Antiparasitic Agents: Part VI--Synthesis of 1,2-,1,3-&1,4-Bis(4-substituted aryloxy)benzenes & Their Biological Activities", Indian Journal of Chemistry, (1988) 27B:38-42.
Kaisex, B. and Hauptmann, J.: Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and Pespectives Cardioval--Drug Reviews. vol. 12, No. 3, pp. 225-236, 1994.
Delgado, J.N. and Remers, W.A.: Textbook of Organic Medicinal and Pharmaceutical Chemistry. Ninth Edition. pp. 30-31, 1991.
Kochanny Monica
Mohan Raju
Morrissey Michael M.
Ng Howard P.
Aulakh Charanjit S.
Berlex Laboratories Inc.
Roth Carol J.
Rotman Alan L.
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