Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1997-11-25
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462751, A61K 3144, C07D40110, C07D40310
Patent
active
056913648
ABSTRACT:
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
REFERENCES:
patent: 4064169 (1977-12-01), Hamano et al.
patent: 5332822 (1994-07-01), Misra
Chauhan, P. et al., "Effect of new diamidines against Leishmania donovani infection," Indian Journal of Experimental Biology, (1993) 31:196-198.
Ashley, J. et al., "The Search for Chemotherapeutic Amidines. Part XVI. Amidinoanilino-1,3,5-triazines and Related Compounds", J. of the Chemical Society, (1960) 4525:4532.
Geratz, J. et al., "The Inhibition of Urokinase by Aromatic Diamidines" Thrombos. Diathes haemorrh. (Stuttg.), (1975)33:230-243.
Geratz, J. et al. "Novel Bis (benzamidino) Compounds with an Aromatic Central Link. Inhibitors of Thrombin, Pancreatic Kallikrein, Trypsin, and Complement" J. of Medicinal Chemistry, (1976) 19(5):634-639.
Chauhan, P. et al., "Antiparasitic Agents: Part VI -Synthesis of 1,2-,1,3-&1,4-Bis(4-substituted aryloxy)benzenes & Their Biological Activities", Indian Journal of Chemistry, (1988) 27B:38-42.
Tidwell, R. et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors, Xa Inhibitors Versus Thrombin Inhibitors," Thrombosis Research, (1980) 19:339-349.
Sturzebecher, J. et al., "Cyclic Amides of N.alpha.-arysulfonylaminoacylated 4-amidinophenylalanine -Tight Binding Inhibitors of Thrombin," Thrombosis Research, (1983) 29:635-642.
Kikumoto, R. et al., "Selective inhibition of Thrombin by dinecarboxylic Acid," Biochemistry, (1984) 23:85-90.
Sturzebecher, J. et al., "Synthetic Inhibitors of Serine Proteinases XXIII, Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) 17:545-548.
Buckman Brad O.
Davey David D.
Guilford William J.
Morrissey Michael M.
Ng Howard P.
Berlex Laboratories Inc.
Roth Carol J.
Rotman Alan L.
LandOfFree
Benzamidine derivatives and their use as anti-coagulants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzamidine derivatives and their use as anti-coagulants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzamidine derivatives and their use as anti-coagulants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2107439