Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-18
2006-04-18
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S212010, C514S424000, C546S192000, C540S484000, C548S541000
Reexamination Certificate
active
07030138
ABSTRACT:
A compound of a formula (1) and pharmacologically acceptable salts thereof:wherein R1represents hydrogen, halogen, alkyl or hydroxyl; R2represents hydrogen or halogen; R3represents hydrogen, alkyl, hydroxyl, carboxyalkyl, alkoxycarbonylalkyl, alkylsulfonyl, alkoxycarbonylalkylsulfonyl, craboxyalkylsulfonyl or carboxyalkylcarbonyl; each of R4and R5represents hydrogen, halogen, alkyl, carbamoyl, alkoxy, carboxyl, alkoxycarbonyl, monoalkylcarbamoyl or dialkylcarbamoyl; R6represents a heterocycle, hydrogen, alkyl, cycloalkyl, aralkyl, carboxyalkyl, alkoxycarbonyalkyl, aliphatic or aromatic acyl, carbamoyl, alkylsulfonyl, aryl, formimidoyl, 1-iminoalkyl, N-alkylforminidoyl or iminoarylmethyl; each of R7and R8represents hydrogen or alkyl; n represents 0, 1 or 2. The compound exhibits excellent activated blood coagulation factor X inhibitory activity and prevents or treats blood coagulation-related diseases.
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English-language International Preliminary Examination Report transmitted on Nov. 4, 2003 of International Application No. PCT/JP02/03355; Applicants: Sankyo Company, Limited.
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Asai Fumitoshi
Fujimoto Koichi
Shimada Ikuko
Tanaka Naoki
Davis Zinna Northington
Frishauf Holtz Goodman & Chick P.C.
Sankyo Company Limited
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