Benzamide inhibitors of the P2X 7 receptor

Details Benzamide inhibitors of the P2X 7 receptor Benzamide inhibitors of the P2X 7 receptor

2007-03-06

2007-03-06

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S461000, C514S380000, C514S398000, C548S369100, C548S255000, C548S247000, C548S331100, C548S343500, C548S333500, C549S474000

Reexamination Certificate

active

10844251

ABSTRACT:
The present invention provides benzamide inhibitors of the P2X7receptor of the formula:wherein R1–R3are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

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