Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-03-31
1996-05-28
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514221, 514249, 540460, 540517, 540518, 544354, C07D24144, C07D24312, C07D24506, C07D24136
Patent
active
055211704
ABSTRACT:
Compounds having the structure below ##STR1## and pharmaceutically acceptable salts thereof exhibit vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for inhibiting saccharide release in the liver, activity for inhibiting growth of mesagium cells, water diuretic activity, platelet agglutination inhibitory activity, oxytocin antagonistic activity and the like, and are useful in treating or preventing hypertension, heart failure, renal insufficiency, edema, ascites, vasopressin parasecretion syndrome, hepatocirrhosis, hyponatremia, hypokalemia, diabetic or circulation disorder, oxytocin related diseases and the like.
REFERENCES:
patent: 5244898 (1993-09-01), Ogawa et al.
patent: 5258510 (1993-11-01), Ogawa et al.
Database WPI, Derwent Publications, WO 9401113,(Jan. 20, 1994), JP-175566, Jul. 2, 1992.
Database WPI, Derwent Publications, WO 9105-549, (May 2, 1991), JP-181858, Jul. 9, 1990.
Database WPI, Derwent Publications, EP 514667, Apr. 19,1991, JP-087994, Nov. 25, 1992.
Hemmi Keiji
Ohkawa Takehiko
Setoi Hiroyuki
Tanaka Hirokazu
Zenkoh Tatsuya
Datlow Philip I.
Fujisawa Pharmaceutical Co. Ltd.
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