Benzamide derivative analgesics

Details Benzamide derivative analgesics Benzamide derivative analgesics

1980-12-08

1982-08-24

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

424324, 549333, 549342, 564161, 564166, 564168, 564177, 564185, A61K 31335, A61K 31165, C07D31904, C07C10322

Patent

active

043461018

ABSTRACT:
Benzamide derivative analgesic compounds of the formula ##STR1## wherein P, Q, R.sub.1, R.sub.2, X and Y are as defined in the specification, e.g., 3,4-Dichloro-N-[[8-(dimethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]methyl]benz amide, and their pharmacologically acceptable salts, have analgesic drug properties with a low ratio of analgesic to sedative activity for use as analgesic drugs in mammalian animals, including humans.

REFERENCES:
patent: 3975443 (1976-08-01), Harper
patent: 4065573 (1977-12-01), Lednicer
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4212878 (1980-07-01), Lednicer et al.
British Journal of Pharmacology, 49 (1973), "Anti-Nociceptive Effects in N-Substituted Cyclohexylmethylbenzamides" by R. T. Brittain et al., pp. 158P-159P.
Journal of Medicinal Chemistry, 17 (1974), "1-(3,4-Dichlorobenzamidomethyl)Cyclohexyldimethylamine and Related Compounds as Potential Analgesics" by N. J. Harper et al.

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