Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-02-18
2000-12-05
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514241, 514247, 514246, 514249, 514258, 514261, 514301, 514303, 514311, 514313, 514352, 514384, 540180, 540184, 544182, 544194, 544224, 544254, 544277, 544280, 544258, 544298, 544322, 544336, 544331, 544362, 546113, 546117, 546118, 546119, 546122, 546164, 546174, A61K 31437, A61K 31519, C07D47104, C07D48704, A61P 912
Patent
active
061567663
ABSTRACT:
Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of this compound and a pharamaceutically acceptable additive, and therapeutic agents for hypertension, therapeutic agents for angina pectoris, therapeutic agent for asthma, therapeutic agents for renal and peripheral circulatory disturbances and inhibitor of cerebral vasospasm, which comprise this compound. The compound of the present invention has strong smooth muscle relaxing action, and shows hypertensive action and cerebral.cndot.coronary vasodilating action like conventional calcium antagonists, as well as long-lasting renal and peripheral circulation improving action. Unlike calcium antagonists, it permits oral administration to suppress vascular contraction caused by various agonists, and is useful as a strong and long-acting agent for prophylaxis and treatment of circulatory diseases in coronary, cerebral, renal and peripheral arteries, as a therapeutic agent for hypertension, angina pectoris, and renal and peripheral circulation disorder, an inhibitor of cerebral vasospasm and the like. Moreover, the compound of the present invention is useful as a therapeutic agent for asthma.
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Arita Masafumi
Minoguchi Masanori
Saitoh Tadamasa
Satoh Hiroyuki
Yamagami Keiji
Huang Evelyn Mei
Yoshitomi Pharmaceutical Industries Ltd.
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