Benzamide compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S268100

Reexamination Certificate

active

07897778

ABSTRACT:
The invention concerns benzamide compounds of Formula (I), wherein R1a, R1b, R1c, R2, R3, R4, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).

REFERENCES:
patent: 4482437 (1984-11-01), Toomey, Jr.
patent: 5256668 (1993-10-01), Hsu et al.
patent: WO 03/024448 (2003-03-01), None
patent: WO 03024448 (2003-03-01), None
patent: WO 03/048164 (2003-06-01), None
patent: WO 03048164 (2003-06-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 03087057 (2003-10-01), None
patent: WO 03/092686 (2003-11-01), None
patent: WO 2005/032493 (2005-04-01), None
patent: WO 2005032493 (2005-04-01), None
David M. Andrews. Oral Small Molecule Anti-Cancer Lead Optimization: Lessons in Campaign Design, Synthesis and Testing, 236th ACS National Meeting, Philadelphia, PA, Aug. 17-21, 2008, (Lecture given on Aug. 21).
Andrews D.M. et al, “Design and Campaign Synthesis of Piperidine- and Thiazole-Based Histone Deacetylase Inhibitors”, Bioorganic and Medicinal Chemistry Letters, 2008, 18, 2580-2584.
Andrews D.M. et al, “Design and Campaign Synthesis of Pyridine-Based Histone Deacetylase Inhibitors”, Bioorganic and Medicinal Chemistry Letters, 2008, 18, 2525-2529.
Final rejection from US PTO for U.S. Appl. No. 10/509,941 (corresponds to WO 03/087057 A).
Beato, M. J. et al. “Chromatin structure and the regulation of gene expression: remodeling at the MMTV promoter” J. Med. Chem., 74(12), pp. 711-724 (1996).
Finnin, M. S. et al. “Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors” Nature, 401(6749), pp. 188-193 (1999).
Gabbianelli, M. “Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiated by sodium butyrate” Blood, 95(11), pp. 3555-3561 (2000).
Li, S. et al. “Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylation.” J. Bio. Chem., 274(12), pp. 7803-7815 (1999).
Marks, P. et al. “Histone deacetylases and cancer: causes and therapies” Nat. Rev. Cancer, 1(3), pp. 194-202 (2001).
Meinke, P. T. et al. “Histone deacetylase: a target for antiproliferative and antiprotozoal agents” Curr. Med. Chem., 8(2), pp. 211-235 (2001).
Miller, T. A. et al. “Histone deacetylase inhibitors” J. Med. Chem., 46(24), pp. 5097-5116 (2003).
Steffan, J. S. et al. “Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration inDrosophila” Nature, 413(6857), pp. 739-743 (2001).
Taylor, E. C. et al. “Synthesis and biological activity of L-5-deazafolic acid and L-5-deazaaminopterin: synthetic strategies to 5-deazapteridines” J. Org. Chem., 48(25), pp. 4852-4860 (1983).
Ukhov, S. V. et al. “Naphthyridines. 14. 2-methylquinoline-3-carboxanilides and the synthesis therefrom of 2-substituted 1-oxo-3-phenyl-1,2,3,4-tetrahydrobenzo[b-1,6]-naphthridines” Chemistry of Heterocyclic Compounds, 25(2), pp. 196-197 (1989).
Wolffe, A. P. et al. “Transcriptional control. Sinful repression” Nature, 387(6628), pp. 16-17, (1997).
Yoshida, M. et al. “Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A” Exper. Cell Res., 177(1), pp. 122-131 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Benzamide compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzamide compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzamide compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2689045

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.