Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-08-30
1998-05-26
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514464, 514465, 514617, 514619, 514620, 514621, 544264, 549441, 564163, 564164, 564166, 564183, C07C23546, C07D47500, A61K 31165, A61K 3141
Patent
active
057565104
ABSTRACT:
A range of 3-oxybenzamide compounds and related quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed include 3-benzyloxybenzamides, 3-oxybenzamides in which a chain of 5 or more methylene groups terminate in a halogen atom or in a purin-9-yl moiety, certain benzoxazole-4-carboxamide compounds and certain quinazolinone compounds. In formula X and Y together may form a bride --X--Y-- that represents the grouping (a), (b) or (c )wherein R.sup.5 is H, alkyl, aryl or aralkyl.
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Chemical Abstracts 54: 13054e.
Calvert Alan Hilary
Curtin Nicola Jane
Golding Bernard Thomas
Griffin Roger John
Newell David Richard
Newcastle University Ventures Limited
Rao Deepak R.
Shah Mukund J.
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