Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1977-08-18
1979-02-27
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
546271, 546328, 546315, 424263, 424273R, 544342, 548327, 548330, 548331, A61K 31415, C07D23516
Patent
active
041419820
ABSTRACT:
New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.
REFERENCES:
Chemical Abstracts Sixth Collective Index, vols. 51-55, 1957-1961, Subjects A-Bi, p. 1533s.
Chemical Abstracts Fifth Decennial Index, vols. 41-50, 1947-1956, Subjects B-Bz, p. 1636s.
Grantham et al., J. Chem. Soc. C (London), 1969, pp. 70-74.
Ferrini Pier G.
Habicht Ernst
Sallmann Alfred
Ciba-Geigy Corporation
Maitner John J.
Trousof Natalie
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