Benz[4,5]imidazole-containing angiotensin antagonists

Details Benz[4,5]imidazole-containing angiotensin antagonists Benz[4,5]imidazole-containing angiotensin antagonists

1990-05-22

1992-12-15

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 548101, 548252, 548254, 5483107, 5483044, A61K 3141, A61K 31415, C07D25704, C07D23508

Patent

active

051717484

ABSTRACT:
The invention concerns novel heterocyclic compounds of the formula I as defined herein and their physiologically acceptable salts, together with pharmaceutical compositions containing them. The heterocyclic compounds antagonize the actions of angiotensin II and are of value in treating diseases or medical conditions such as hypertension and congestive heart failure in warm-blooded animals. The invention further includes processes for the manufacture of the novel compounds and their use in medical treatment.

REFERENCES:
patent: 4612323 (1986-09-01), Kisida et al.
patent: 4663339 (1987-05-01), Kisida et al.
patent: 4820843 (1989-04-01), Aldrich et al.
patent: 4859692 (1989-08-01), Bernstein et al.
patent: 4870186 (1989-09-01), Aldrich et al.
patent: 4874867 (1989-10-01), Aldrich et al.
patent: 4880804 (1989-11-01), Carini et al.
patent: 5051530 (1991-09-01), Chang et al.
Sinkula, A. A. "Prodrug Approach in Drug Design" In Ann. Rep. Med. Chem. (1975), 10, 306-316.
Stella, V. "Pro-drugs: An Overview and Definition" and Sinkula, A. A. "Application of the Pro-drug Approach to Antibiotics" In Pro-Drugs as Novel Drug Delivery Systems; Higuchi, T. and Stella V. Eds.; ACS Symposium Series 14, American Chemical Society: Washington, DC, 1975; pp. 1-15, 44-45, 116-153.
Bundgaard, H. "Design of prodrugs: Bioreversible derivatives for various functional groups and chemical entities" In Design of Prodrugs; Bundgaard, H., Ed.; Elsevier Science Publishers: Amsterdam, 1985; pp. 1-10.
Bundgaard, H., "Design of Bioreversible Drug Derivatives and the Utility of the Double Prodrug Concept" In Bioreversible Carriers in Drug Design; Roche, E. B., Ed.; Pergamon Press: New York, 1987; pp. 13-21.

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