Winding – tensioning – or guiding – Strand tensioning device – Tortuous course
Patent
1996-02-20
1999-01-12
Lilling, Herbert J.
Winding, tensioning, or guiding
Strand tensioning device
Tortuous course
424439, 424464, 424475, A61K 3578
Patent
active
058583700
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
This invention relates to the beneficial effects of plant volatile oils in a human or non-human body.
Oils from various sources have been known to have a beneficial effect in humans and animals and can provide vitamins, fats and other life-enhancing chemicals. Examples of such oils are fish oil, such as cod-liver oil.
Plant volatile oils, in particular from Thymus vulgaris, have been shown by the inventors to have beneficial effects on various tissues in the body.
From the present data, it appears that at least some of the beneficial effects of plant volatile oils on human or non-human bodies are connected with the levels of polyunsaturated fatty acids (PUFAs) in the bodies.
SUMMARY OF THE INVENTION
According to the present invention there is provided the use of a plant volatile oil or a constituent thereof and/or
DETAILED DESCRIPTION OF THE INVENTION
The term "plant volatile oil" is used herein to refer to any organic oil or fatty substance derivable from plants by distillation and includes synthetic equivalents of such volatile oils-as well as equivalent oils from other, non-plant, sources. A constituent of a plant volatile oil is any ingredient found in a plant volatile oil which causes or contributes to the effect required in the invention.
The term "combat" as used herein refers to the prevention of a condition (ie prophylactic use) as well as treatment of an existing condition to ameliorate that condition or to delay or prevent its further deterioration.
The "deleterious changes in nervous tissue" mentioned above in part (b) may comprise degeneration of nervous tissue, changes in morphology or structure of nerve cells present in the tissue, reduction in the number of nerve cells present in the tissue, and reduction in nervous tissue function (not necessarily accompanied by morphological changes).
In a preferred aspect the present invention provides the use of a plant volatile oil for the purpose of any of parts (b) to (h) above.
Further according to the invention there is provided the use of a plant volatile oil or a constituent thereof for the manufacture of a medicament for the purpose of any of parts (a) to (h) above.
In another preferred aspect the present invention provides the use of a plant volatile oil for the manufacture of a medicament for the purpose of any of parts (b) to (h) above.
Further according to the invention there is provided a method of and/or volatile oil or a constituent thereof to said body.
Preferably, the plant volatile oil is administered in a sufficient concentration to prevent substantial diminution of the level of essential long chain PUFAs of metabolic significance, such as arachidonic acid, eicosapentanoic acid and/or docosohexaenoic acid in the body. The plant volatile oil may be administered in a daily amount of not less than 15 mg per 50 kg of animal body weight, preferably not less than 20 mg per 50 kg and most preferably not less than 25 mg per 50 kg.
Plant volatile oils which have been found to have the beneficial effects stated above are those derivable from clove, nutmeg, pepper, thyme, paprika, oregano, marjoram, basil and French tarragon. Most preferably, the plant volatile oil is derived from thyme or clove. Oils or constituents thereof may be used alone or in combination with other oils or constituents.
The neuropeptide mentioned is generally selected from neuropeptide Y, substance P, somatostatin, vasoactive intestinal polypeptide, serotonin and dopamine B-hydroxylase.
The nervous tissue mentioned may be, but is not limited to, small intestinal neural tissue.
Optionally, the protein levels mentioned in parts (d) and (e) are elevated to the extent that the ratio of creatinine excretion (in mg per 24 hours) to 3-methyl histidine excretion (in .mu.mol per 24 hours) is reduced by about a factor of 2-3.
The plant volatile oil or constituent thereof may be administered together with a pharmaceutical carrier and may be simply admixed therewith or chemically linked thereto. Alternatively the plant volatile oil or constituent the
REFERENCES:
patent: 4980169 (1990-12-01), Oppenheimer et al.
"Promotional Effects of Planet Volatile Oils on the Polyunsaturated Fatty Acid Status during aging", S. G. Deans et al, Age, vol. 16, 1993, pp. 71-74
Natural Antioxidants from Aromatic and Medicinal Plans, S. G. Deans et al., in Role of Free Radicals in Biological Systems, 1993, pp. 159-165
International Search Report for PCT/GB94/01833 (priority date: Aug. 20, 1993)
U. K. Search Report for GB2 282 532 (corresponding to the present application) dated 21 Nov. 1994.
Deans Stanley Gordon
Noble Raymond Clifford
Lilling Herbert J.
Scottish Agricultural College
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