Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-06-08
1984-05-29
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
A61K 31415
Patent
active
044514778
ABSTRACT:
It was discovered that bendazac, or [(1-benzyl-1H-indazol-3-yl)oxy] acetic acid, when administered in a form suitable to obtain therapeutic tissue concentrations, determines a regression of cataract. It was demonstrated in particular, that the lysine salt of bendazac is well adapted for this use since it produces adequate tissue concentrations following both oral administration and topical application on the eye. The chemical and physical characteristics of this bendazac salt are described here together with the preparation techniques.
REFERENCES:
patent: Re27253 (1971-12-01), Palazzo
patent: 3625970 (1971-12-01), Ambrus
patent: 4282237 (1981-08-01), Silvestrini
patent: 4352813 (1982-10-01), Silvestrini et al.
G. Boschi et al., "L'uso del bendazac lisina (Bendalina) nella terapia della cataratta," Minerva Oftalmologica 24, Reprint (1982) (English Summary).
R. Leoni et al., "Esperienze con Bendalina nella terapia della cataratta," Minerva Oftalmologica 24, reprint (1982) (English Summary).
Michele Testa et al., "Pilot Study of Bendazac for Treatment of Cataract," The Lancet, pp. 849-850 (Apr. 10, 1982).
S. Peralta et al., "Saggio clinico-terapeutico della Bendalina nella cataratta," Il Policlinico-Sez. Medica 89, Reprint (1982).
Baiocchi Leandro
Silvestrini Bruno
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
Robinson Douglas W.
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