Bcl-x/bcl-2 associated cell death regulator

Details Bcl-x/bcl-2 associated cell death regulator Bcl-x/bcl-2 associated cell death regulator

1996-06-10

1998-11-10

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530300, 530324, 530325, 530326, 530327, 530328, 530350, G01N 3353, C07K 704, C07K 1447

Patent

active

058342095

ABSTRACT:
The invention provides a bcl-2 related protein, Bad, Bad muteins, two-hybrid systems comprising interacting Bad polypeptide sequences, Bad polynucleotides, and uses thereof.

REFERENCES:
patent: 4482543 (1984-11-01), Suzuki et al.
patent: 5622852 (1997-04-01), Korsmeyer
Boise et al. (1993), bcl-x, a bcl-2-Related Gene That Functions as a Dominant Regulator of Apoptotic Cell Death, Cell 74:597-608.
Hengartner et al. (1992), Caenorhabditis elegans gene ced-9 Protects Cells from programmed Cell Death, Nature 356:494-9.
Hengartner et al. (1994), C. elegans Cell Survival Gene ced-9 Encodes a Functional Homolog of the Mammalian Proto-Oncogene bcl-2, Cell 76:665-76.
Oltvai et al. (1993), Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, That Accelerates Programmed Cell Death, Cell 74: 609-19.
Vaux et al. (1992), Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2, Science 258:1955-7.
Williams et al. (1993), Molecular Regulation of Apoptosis: Genetic Controls on Cell Death, Cell 74:777-9.
Yin et al (1994), BH1 and BH2 Domains of Bcl-2 are Required for Inhibition of Apoptosis and Heterodimerization with Bax, Nature 369:321-3.
J.A. Wells. Additivity of mutational effects in proteins. Biochemistry. 29(37): 8509-8517, Sep. 18, 1990.

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