Bcl-x/Bcl-2 associated cell death regulator

Details Bcl-x/Bcl-2 associated cell death regulator Bcl-x/Bcl-2 associated cell death regulator

1994-10-31

1997-04-22

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 43525233, 43525411, 435348, 536 234, 536 235, 536 2431, 536 2433, 935 8, 935 11, 935 66, C12N 115, C12N 121, C12N 510, C12N 1512, C07H 2100

Patent

active

056228520

ABSTRACT:
The invention provides a bcl-2 related protein, Bad, Bad muteins, two-hybrid systems comprising interacting Bad polypeptide sequences, Bad polynucleotides, and uses thereof.

REFERENCES:
Boise et al., "bcl-x, a bcl-2-Related Gene That Functions as a Dominant Regulator of Apoptotic Cell Death", Cell, 74:597-608 (1993).
Hengartner et al., "Caenorhabditis elegans gene ced-9 protects cells from programmed cell death", Nature, 356:494-499 (1992).
Hengartner et al., "C. elegans Cell Survival Gene ced-9 Encodes a Functional Homolog of the Mammalian Proto-Oncogene bcl-2", Cell, 76:665-676 (1994).
Oltvai et al., "Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, That Accelerates Programed Cell Death", Cell, 74:609-619 (1993).
Vaux et al., "Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2" Science, 258:1955-1957 (1992).
Williams et al., "Molecular Regulation of Apoptosis: Genetic Controls on Cell Death", Cell, 74:777-779 (1993).
Nunez et al. (1994) The Bcl-2 family of proteins:regulators of cell death and survival. Trends in Cell Biology 4: 399-403.
Yin et al. (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369: 321-323.
Sato et al. (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci., USA, 91: 9238-9242.
Borner et al. (1994) Dissection of functional domains in Bcl-2.alpha. by site-directed mutagenesis. Biochemistry and Cell Biology 72: 463-469.

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