Bcl-2-associated proteins

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 231, 536 245, 4351723, C12N 1500, C07H 2104, C07H 2102

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active

056865953

ABSTRACT:
The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.

REFERENCES:
Gura, Antisense has growing pains, Science 270:575-577, Oct. 1995.
Hodgson, The vector void in Gene Therapy, Biotechnology, 13:222-227, Mar. 1995.
Stein et al, Antisense Oligodeoxynucleotides, Current Opinions in Oncology, 6:67-594, 1994.
Milligan et al, Current Concepts in Antisense Drug Design, Journal of Medicinal Chemistry, 36:(14) 1925-1937, Jul. 1993.
Hanada, Motoi et al., "Regulation of Bc1-2 Oncoprotein Levels with Differentiation of Human Neuroblastoma Cells." Cancer Res.53:4978-4986 (1993).
Tanaka, Shigeki et al, "Structure-Function Analysis of the Bc1-2 Oncoprotein." J. Biol. Chem.268:10920-10926 (1993).
Hockenbery, D. et al., "Bcl-2 is an Inner Mitochondrial Membrane Protein that Blocks Programmed Cell Death." Nature 348:334-336 (1990).
Boise, Lawrence H. "bcl-x, a bcl-2-Related Gene that Functions as a Dominant Regulator of Apoptotic Cell Death." Cell 74:597-608 (1993).
Miyashita, T. and Reed, J.C. "Bcl-2 Oncoprotein Blocks Chemotherapy-Induced Apoptosis in a Human Leukemia Cell Line." Blood 81:151-157 (1993).
Vaux, D.L., "Toward an Understanding of the Molecular Mechanisms of Physiological Cell Death." Proc. Natl. Acad. Sci. USA. 90:786-789 (1993).
Vaux, D. et al., "Bcl-2 Gene Promotes Haemopoietic Cell Survival and Cooperated with c-myc to Immortalize Pre-B Cells." Nature 335:440-442 (1988).
Kocache, Malda M. and Pearson, Gary R. "Protein Kinase Activity Associated with a Cell Cycle Regulated, Membrane-Bound Epstein-Barr Virus Induced Early Antigen." Intervirology 31:1-13 (1990).
Oltvai, Zoltan N. et al., "Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, that Accelerates Programed Cell Death." Cell 74:609-619 (1993).
Nunez, Gabriel et al., "Deregulated Bcl-2 Gene Expression Selectively Prolongs Survival of Growth Factor-Deprived Hemopoietic Cell Lines." J. Immunl. 144:3602-3610 (1990).
Garcia, Irene et al., "Prevention of Programmed Cell Death of Sympathetic Neurons by the Bcl-2 Proto-Oncogene." Science 258:302-304 (1992).
Bissonnette, Reid P et al., "Apoptotic Cell Death Induced by c-myc is Inhibited by Bcl-2." Nature 359:552-554 (1992).
Fanidi, Abdallah et al., "Cooperative Interaction Between c-myc and bcl-2 Proto-Oncogenes." Nature 359:554-556 (1992).
Vaux, David L. et al., "Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2." Science 258:195-197 (1992).
Alnemri Emad S. et al., "Overexpressed Full-Length Human BCL2 Extends the Survival of Baculovirus-infected Sf9 Insect Cells." Proc. Natl. Acad. Sci. USA 89:7295-7299 (1992).
Siegel, Richard M. et al., "Inhibition of Thymoyte Apoptosis and Negative Antigenic Selection in bcl-2 Transgenic Mice." Proc. Natl. Acad. Sci. USA 89:7003-7007 (1992).
Sentman, Charles L. et al., "bcl-2 Inhibits Multiple Forms of Apoptosis but Not Negative Selection in Thymocytes." Cell 67:879-888 (1991).
Strasser, Andreas et al., "bcl-2 Transgene Inhibits T Cell Death and Perturbs Thymic Self-Censorship." Cell 67:889-899 (1991).
McDonnell, Timothy J. et al., "bcl-2-Immunoglobulin Transgenic Mice Demonstrate Extended B Cell Survival and Follicular Lymphoproliferation." Cell 57:78-88 (1989).
Wagner Andrew J. et al., "Myc-Mediated Apoptosis is Blocked by Ectopic Expression of Bcl-2." Mole. Cell Biol. 13(4) 2432-2440 (1993).
Fernandez-Sarabia, Maria J. and Bischoff, James R. "Bcl-2 Associates with the ras-Related Protein R-ras p23." Nature 366:274-275 (1993).
Lee, Sooja et al., "Apoptosis and Signal Transduction: Clues to a Molecular Mechanism." Current Opinion Cell Biol. 5:286-291 (1993).
Donahue et al JE01 176: 1125, 1992.
Coughler in few Scientist, pp. 14 & 15, 25 Nov. 1995.
Marshall et al Science 269: 1050, 1995.
Orkin et al "Report & Recommendations of the Panel to Assess the NIH Investment in Research . . .", Dec., 7, 1995.
Miller et al Parasitology Today 10(3): 92, 1994.

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