Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-08-20
1996-07-23
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 530402, C07K 14435
Patent
active
055390854
ABSTRACT:
The invention provides compositions and methods for screening for agents which are modulators of bcl-2 function and can modulate bcl-2-mediated apoptosis and/or modulate neoplastic and immune conditions dependent upon bcl-2 function. The invention also provides a composition comprising a substantially pure protein complex comprising a R-ras polypeptide and a bcl-2 polypeptide.
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Boguski M. et al., "Proteins regulating Ras and its relatives" in Nature vol. 363, pp. 643-654 (1993).
Lowe D. G. and Goeddel D. V. "Heterologous expression and characterization of the human R-ras gene product" in Mol. Cell. Biol. vol. 7, pp. 2845-2856 (1987).
Tanka S. et al., "Structure-Function Analysis of the Bcl-2 Oncoprotein" in The Journal of Biological Chemistry vol. 268, p. 10920-10926 (1993).
Tsujimoto, Y. and Croce, C. M. "Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma" in Proc. Natl. Acad. Sci. vol. 83, pp. 5214-5218 (1986).
Wong H-G et al., "R-Ras Promotes Apoptosis Caused by Growth Factor Deprivation Via a Bcl-2 Suppressible Mechanism" in J. Cell Biology vol. 129 pp. 1103-1114 (1995).
Bischoff James R.
Fernandez-Sarabia Maria J.
Draper Garnette D.
Dunn Tracy
Giotta Gregory
ONYX Pharmaceuticals, Inc.
Teng Sally P.
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