Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-10-10
2000-10-03
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 235, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2104
Patent
active
061271187
ABSTRACT:
Nucleic acid probes substantially complementary to nucleic acid sequences within the bcl-1 locus are disclosed as well as polymerase chain reaction (PCR) primers substantially complementary to nucleic acid sequences within that locus that are useful in detecting t(11;14)(q13;q32) translocations associated with hematopoietic cancers. Further, the bcl-1 locus probes are useful in detecting bcl-1 amplifications found in about twenty percent of solid tumors, particularly in squamous cell and mammary carcinomas. Diagnostic/prognostic methods for cancer are disclosed, as well as cancer research methods using the bcl-1 probes of this invention.
REFERENCES:
Arnold et al. Journal of Clinical Investigation. 83: 2034-2040, 1989.
Arnold et al. Cold Spring Harbor Symposia on Quantitative Biology. 93-97, 1991.
Meeker et al. Blood. 74:1801-1806, 1989.
Meeker et al. Leukemia. 5:733-737, 1991.
Medeiros et al. Blood. 76:2086-2090, 1990.
Lee et al. Polymerase Chain Reaction. Cold Spring Harbor Laboratory Press, pp. 31-35, 1989.
Lammie et al. Oncogene. 6;439-444, 1991.
Motokura et al. Nature. 350:512-515, 1991.
Withers et al. Molecular and Cellular Biology. 11:4846-4853, 1991.
Rosenberg. Proceedings of the National Academy of Sciences, USA. 88: 9638-9642, 1991.
Korenberg. Trends in BioTechnology. 10:27-32, 1992.
Sambrook et al. Molecular Cloning: A Laboratory Manual. 7.37-7.77, Cold Spring Harbor Laboratory Press, N.Y., 1989.
Myers Carla J.
The Regents of the University of California
LandOfFree
bcl-1 locus nucleic acid probes and assay methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with bcl-1 locus nucleic acid probes and assay methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and bcl-1 locus nucleic acid probes and assay methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-193752