Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-10
2007-04-10
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024100, C435S007100, C436S501000, C436S518000
Reexamination Certificate
active
09953133
ABSTRACT:
The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptotic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. The present invention is further directed to a method for modulating apoptosis in a cell, a method for modulating bbc3 gene expression in a cell, a process for making a modulator of apoptosis, and a process for making a modulator of bbc3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.
REFERENCES:
patent: WO 99/50280 (1999-10-01), None
patent: WO 00/60092 (2000-10-01), None
patent: WO 01/23522 (2001-04-01), None
patent: WO 02064790 (2002-08-01), None
NCBI accession No. AC000852.5 (Jul. 18, 2000) downloaded from NCBI website on May 5, 2005.
Nakano, et al.,PUMA, a Novel Proapoptotic Gene, is Induced by p53, Mol. Cell7:684-694 (2001).
Yu, et al.,PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cell, Mol. Cell7:673-682 (2001).
Han et al.PNAS USA98(20):11318-11323(2001).
Chittenden Thomas
Han Jia-Wen
Immunogen Inc.
Sughrue & Mion, PLLC
Yu Misook
LandOfFree
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