Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Cell membrane or cell surface is target
Patent
1997-07-17
2000-02-08
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Cell membrane or cell surface is target
4351735, 4351737, 436 1, 436 5, 436 63, 436149, 436800, 436805, 436806, 436808, 436829, C12N 1300, G01N 33483, G01N 2700
Patent
active
060227206
ABSTRACT:
The present invention relates, in general, to a protein that regulates programmed cell death and, in particular, to the pro-apoptotic protein, Bax, which forms channels in lipid membranes. The invention further relates to methods of identifying agonists and antagonists of Bax channel formation and/or activity and thereby agents that can be used therapeutically to promote or inhibit cell death.
REFERENCES:
Korsmeyer et al, Bcl-2 Gene Family in Development and Oncogenesis, Proceedings Programmed Cell Death, Oct. 1923, 1996.
Winkowski et al. Applied and Environmental Microbiology. (1996) 62/2 (323-327).
Tomita et al Journal of Biological Chemistry, Jul. 5, 1992, vol. 267, No. 19, pp. 13391-13397.
Zalman et al Infection and Immunity Dec. 1985, vol. 50 (3) 630-635
Shin et al Biochimica et Biophysica Acta, Jul. 19, 1979, vol. 555 (1) 79-88 .
Antonsson Bruno
Conti Franco
Martinou Jean-Claude
Mazzei Gonzalo
Sadoul Remy
Bansal Geetha P.
Glaxo Wellcome Inc.
Hutzell Paula K.
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